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Postdoctoral Fellow
Posted by:
Yale Stem Cell Center and Genetics
Posted date:
30-Sep-09
A newly established laboratory at Yale Stem Center and Genetics Department is inviting applications to multiple postdoctoral positions. With an emphasis on histone variants, modifications and chromatin remodeling complexes, the lab focuses on investigating molecular mechanisms for mammalian stem cell biology (toti- and pluri-potent), cellular reprogramming (iPS) and embryonic development.
Our research has revealed several new functions of histone variant H2A.X and its novel kinase WSTF in maintaining genome integrity (Nature(2009) V457, 57-62 ). Our latest findings motivate us to investigate how H2A.X and WSTF coordinate genome integrity and gene expression during reprogramming (iPS). Since WSTF is frequently deleted in human Williams Syndrome, we are investigating its role during development, especially in neural crest cells. We have multiple well-defined projects available using biochemistry, cell biology, mouse genetics, and genomics & bioinformatics (Chip-Seq and RNA-Seq) tools to study these questions. These projects are partly supported by a NCI Howard Teming Award (K99/R00).
A successful candidate should be self-motivated with a strong background and experimental skills in molecular biology, as well as a track record of publication. Previous experiences in aforementioned fields are welcome but not required. Yale Stem Cell Center and Department of Genetics provide a stimulating and collaborative training environment. We are enjoying collaborations with many world-renown faculty members at Yale. Interested applicants please send CV and contact information of three referees to: Andrew Xiao, Assistant Professor at Stem Cell Center and Department of Genetics, Yale University School of Medicine, Xiaoa Rockefeller.edu
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